jeudi 1 janvier 2015
Hair Loss:Randomized Placebo Controlled Clinical Trial of Tocomin SupraBio™ for Androgenetic Alopecia
Study Design A n 8-month study was performed at the School of Pharmaceutical Sciences, University of Science Malaysia with 28 volunteers aged 18 to 59 years with mild to moderately severe hair loss. The volunteers had hair loss problem for approximately 2-5 years and most of them had hair loss pattern scale III according to the Norwood/Hamilton classification scale. They were instructed not to alter their hairstyle, hair care products (shampoo, conditioners, etc) or dye their hair during the study period. The volunteers were randomly selected to receive palm tocotrienol complex (Tocomin ® SupraBio™, Carotech Inc.) or the placebo – soft gelatin capsule containing 600 mg soya bean oil – for 8 months. The total daily intake of tocotrienols for each volunteer in the treatment group was 100 mg. Hair counts and weight of hair in pre-selected evaluation area were measured before and every month after initiation of the study.">Tocomin ® SupraBio™ ensures
approximately 300% increase in oral
absorption of tocotrienols via a special
self-emulsifying formulation (10). It is an
advanced formulation of Tocomin ®, a
natural tocotrienol complex concentrated
from virgin crude palm oil through a
patented mild extraction process that
ensures maximum preservation of
phytonutrients. Tocomin ® SupraBio™ is
the most bioavailable tocotrienol
complex available in the market.
Tocotrienols are fat-soluble vitamins
related to tocopherols – the common
vitamin E. Whilst tocopherols occur
naturally in common vegetable oils;
tocotrienols are concentrated in cereal
g rains, e.g. oat, barley, rice bran, with
virgin crude palm oil being the richest
source. Tocotrienols differ from
tocopherols by having an unsaturated
side tail that results in significantly
different biological activities. Recent new
studies brought to light many unique
benefits of tocotrienols not shared by
tocopherols.
Beneficial effects of
vitamin E in hair care
products have been
reported (11) although
lacking formal
investigation. We
conducted a double
blind placebo-controlled
clinical trial on
volunteers with
androgenetic alopecia
(male pattern baldness)
to evaluate the efficacy
of palm tocotrienol
complex oral
supplementation.
Study Design
A n 8-month study was
performed at the School of
Pharmaceutical Sciences, University of
Science Malaysia with 28 volunteers
aged 18 to 59 years with mild to
moderately severe hair loss. The
volunteers had hair loss problem for
approximately 2-5 years and most of
them had hair loss pattern scale III
according to the Norwood/Hamilton
classification scale. They were instructed
not to alter their hairstyle, hair care
products (shampoo, conditioners, etc) or
dye their hair during the study period.
The volunteers were randomly
selected to receive palm tocotrienol
complex (Tocomin ® SupraBio™,
Carotech Inc.) or the placebo – soft
gelatin capsule containing 600 mg soya
bean oil – for 8 months. The total daily
intake of tocotrienols for each volunteer
in the treatment group was 100 mg.
Hair counts and weight of hair in
pre-selected evaluation area were
measured before and every month after
initiation of the study.
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